Detection of oligoclonal immunoglobulins in cerebrospinal fluid by an immunofixation-peroxidase method.

@article{Richard2002DetectionOO,
  title={Detection of oligoclonal immunoglobulins in cerebrospinal fluid by an immunofixation-peroxidase method.},
  author={Sophie Richard and V{\'e}ronique Miossec and J Moreau and J L Taupin},
  journal={Clinical chemistry},
  year={2002},
  volume={48 1},
  pages={167-73}
}
BACKGROUND The detection of intrathecal synthesis of immunoglobulins is used in the diagnosis of multiple sclerosis (MS). We tested the semiautomated immunofixation-peroxidase (IFPOD) technique, which uses high-resolution agarose gel electrophoresis (HRAGE) directly followed by immunofixation with a peroxidase-labeled anti-IgG antiserum to detect oligoclonal immunoglobulins in cerebrospinal fluid (CSF). METHODS We analyzed 230 consecutive matched serum/CSF pairs that arrived in the laboratory… CONTINUE READING

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