Detection of occult melanoma cells in blood with a multiple-marker polymerase chain reaction assay.

@article{Hoon1995DetectionOO,
  title={Detection of occult melanoma cells in blood with a multiple-marker polymerase chain reaction assay.},
  author={Dave S B Hoon and Yixin Wang and P Steven Dale and Andrew J Conrad and Peter Schmid and Deanna Garrison and Christine Kuo and Leland J. Foshag and A J Nizze and Donald L. Morton},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1995},
  volume={13 8},
  pages={2109-16}
}
PURPOSE The objective of the study was to develop a sensitive multimarker polymerase chain reaction (PCR) assay to detect circulating melanoma cells in patient blood. The rationale was that malignant melanoma is heterogeneous in regards to antigen expression. PATIENTS AND METHODS A PCR assay that uses four melanoma-associated gene markers (tyrosinase, p97, MUC18, and MAGE-3) was developed. Sensitivity and specificity of the PCR assay for individual markers were assessed using 10 melanoma cell… CONTINUE READING
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