Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography.

  title={Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography.},
  author={Peter A. Underhill and Li Jin and Alice A. Lin and Syed Qasim Mehdi and Trefor Jenkins and Douglas Vollrath and R W Davis and Luigi Luca Cavalli-Sforza and Peter J. Oefner},
  journal={Genome research},
  volume={7 10},
Y chromosome haplotypes are particularly useful in deciphering human evolutionary history because they accentuate the effects of drift, migration, and range expansion. Significant acceleration of Y biallelic marker discovery and subsequent typing involving heteroduplex detection has been achieved by implementing an innovative and cost-efficient method called denaturing high-performance liquid chromatography (DHPLC). The power of the method resides in its sensitivity and ability to rapidly… 

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