Detection of novel polymorphisms in the ckit gene of canine patients with lymphoma, melanoma, haemangiosarcoma, and osteosarcoma

@article{Gramer2016DetectionON,
  title={Detection of novel polymorphisms in the ckit gene of canine patients with lymphoma, melanoma, haemangiosarcoma, and osteosarcoma},
  author={Irina Gramer and Martin Kessler and Joachim Geyer},
  journal={Veterinary Research Communications},
  year={2016},
  volume={40},
  pages={89-95}
}
Tyrosine kinase inhibitors (TKIs) that specifically target cKIT represent a therapeutic approach for non-resectable canine mast cell tumours (MCTs) grade II/III. The therapeutic benefit of TKIs has been investigated in other tumours based on clinical response rates and identification of gain-of-function mutations. In the present study, cKIT expression in 14… CONTINUE READING