Detection of neurodegenerative disease using olfaction

  title={Detection of neurodegenerative disease using olfaction},
  author={Michael S. Xydakis and Leonardo Belluscio},
  journal={The Lancet Neurology},
Olfactory Dysfunction in Neurodegenerative Diseases
The neurobiology of olfaction, and the most common olfactory function measurements in neurodegenerative diseases, and its value as a clinical marker for early stages of the diseases when combined with other clinical, biological, and neuroimage markers are described.
Clinical, Structural, and Neuropathological Features of Olfactory Dysfunction in Patients with Alzheimer's Disease.
Overall, in AD patients, the impairments in olfactory discrimination and identification seems to be more correlated with cognitive levels, which may be an indicator of pathological cognitive decline and structural changes.
Noradrenergic Modulation of the Piriform Cortex: A Possible Avenue for Understanding Pre-Clinical Alzheimer’s Disease Pathogenesis
The role of LC-sourced NE in modulation of PC activity is reviewed and mechanisms by which pretangle tau-mediated LC dysfunction may impact olfactory processing in preclinical stage of AD are suggested.
Clinical Implications of Psychophysical Olfactory Testing: Assessment, Diagnosis, and Treatment Outcome
Recent advancements should promote the understanding of psychophysical olfactory testing, the association between individual subcomponents and neurophysiological processes, and pave the way for precision assessment and treatment of the Olfactory dysfunction.
Testing Olfactory and Gustatory Dysfunctions among Quarantine COVID-19 Suspects
In this study, testing of smell and taste dysfunctions had higher sensitivity in identifying recent-onset loss of sensations in COVID-19 cases and may be used as a simple and cost-effective screening test.
Atypical otolaryngologic manifestations of COVID-19: a review
It is crucial for ENT physicians to have high index of suspicion to identify those COVID 19 patients with atypical presentations to facilitate early case isolation to eliminate viral spread across the community.
Disposable Morpho menelaus Based Flexible Microfluidic and Electronic Sensor for the Diagnosis of Neurodegenerative Disease
A flexible Morpho menelaus based wearable sensor integrated with a microfluidic system and electronic networks to facilitate the diagnosis of neurodegenerative disease (ND) and enables biochemical-physiological hybrid monitoring of ND.


Sniffing the diagnosis: Olfactory testing in neurodegenerative parkinsonism.
Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD
Assessment of olfactory function, particularly odor identification, may help to predict the development of a Lewy body disease in patients with iRBD over a relatively short time period and thus to identify patients suitable for future disease modification trials.
A brief olfactory test for Alzheimer's disease
Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia.
Olfactory impairment is associated with incident aMCI and progression from a MCI to AD dementia, and olfactory tests have potential utility for screening for MCI and MCI that is likely to progress, consistent with previous studies.
Olfactory deficits predict cognitive decline and Alzheimer dementia in an urban community
Impairment in odor identification was superior to deficits in verbal episodic memory in predicting cognitive decline in cognitively intact participants, and the findings support the cross-cultural use of a relatively inexpensive odor identification test as an early biomarker of cognitive decline and AD dementia.
Office Procedures for Quantitative Assessment of Olfactory Function
  • R. Doty
  • Medicine
    American journal of rhinology
  • 2007
In this article basic issues related to practical measurement of olfactory function in the clinic are described and examples of the application of the two most common paradigms for such measurement—odor identification and detection—are presented.
Olfactory impairment and traumatic brain injury in blast-injured combat troops
Quantitative identification olfactometry has limited sensitivity but high specificity as a marker for detecting acute structural neuropathology from trauma and should be regarded as an important tool to inform the decision process when considering whether to order advanced neuroimaging.
Association of olfactory dysfunction with risk for future Parkinson's disease
Examination of the association of olfactory dysfunction with future development of PD in Honolulu‐Asia Aging Study cohort members finds that it can predate the onset of clinical PD in a community‐based population.
Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects
The present data suggest specific changes of individual olfactory functions in relation to age, with odor thresholds declining most dramatically compared to odor discrimination and odor identification.