Detection of mutations in glycoprotein hormone receptors.

  title={Detection of mutations in glycoprotein hormone receptors.},
  author={Joerg Gromoll and Martina Broecker and Michael Derwahl and Wolfgang Hoeppner},
  volume={21 1},
The luteinizing, follicle-stimulating, and thyroid-stimulating hormone receptors belong to the huge family of G-protein-coupled receptors. Identification of either activating or inactivating mutations of these receptors has led to a fundamental improvement in our understanding of glycoprotein hormone/receptor interaction. Furthermore, clinical phenotypes such as precocious puberty, follicle-stimulating hormone (FSH) insensitivity syndrome, and congenital hypthyroidism are now being explained by… CONTINUE READING

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