Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer.

@article{Yang2017DetectionOM,
  title={Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer.},
  author={Sujuan Yang and Sara P. Y. Che and Paul Kurywchak and Jena L Tavormina and Liv B. Gansmo and Pedro Correa de Sampaio and Michael Tachezy and Maximilian Bockhorn and Florian Gebauer and Amanda R. Haltom and S{\'o}nia A. Melo and Valerie S LeBleu and Raghu Kalluri},
  journal={Cancer biology & therapy},
  year={2017},
  volume={18 3},
  pages={
          158-165
        }
}
Pancreatic cancer presents with a dismal mortality rate and is in urgent need of methods for early detection with potential for timely intervention. All living cells, including cancer cells, generate exosomes. We previously discovered double stranded genomic DNA in exosomes derived from the circulation of pancreatic cancer patients, which enabled the detection of prevalent mutations associated with the disease. Here, we report a proof-of-concept study that demonstrates the potential clinical… CONTINUE READING
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Circulating biomarkers for early diagnosis of pancreatic cancer: facts and hopes.

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