Detection of mitochondrial dysfunction by EPR technique in mouse model of dilated cardiomyopathy.

@article{Elas2008DetectionOM,
  title={Detection of mitochondrial dysfunction by EPR technique in mouse model of dilated cardiomyopathy.},
  author={Martyna Elas and Joanna Bielańska and Katarzyna Pustelny and Przemyslaw Mieszko Plonka and Lukasz Drelicharz and Tomasz Sk{\'o}rka and Urszula Tyrankiewicz and Miroslaw Wozniak and Sylwia Heinze-Paluchowska and Michał Walski and Leszek Wojnar and Dominique Fortin and R Ventura-clapier and Stefan Chlopicki},
  journal={Free radical biology & medicine},
  year={2008},
  volume={45 3},
  pages={
          321-8
        }
}
Tgalphaq44 mice with targeted overexpression of activated Galphaq protein in cardiomyocytes mimic many of the phenotypic characteristics of dilated cardiomyopathy in humans. However, it is not known whether the phenotype of Tgalphaq44 mice would also involve dysfunction of cardiac mitochondria. The aim of the present work was to examine changes in EPR signals of semiquinones and iron in Fe-S clusters, as compared to classical biochemical indices of mitochondrial function in hearts from… CONTINUE READING
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