Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects

@article{Velden2003DetectionOM,
  title={Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects},
  author={V. Velden and A. Hochhaus and G. Cazzaniga and T. Szczepański and J. Gabert and J. Dongen},
  journal={Leukemia},
  year={2003},
  volume={17},
  pages={1013-1034}
}
Detection of minimal residual disease (MRD) has prognostic value in many hematologic malignancies, including acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia, non-Hodgkin's lymphoma, and multiple myeloma. Quantitative MRD data can be obtained with real-time quantitative PCR (RQ-PCR) analysis of immunoglobulin and T-cell receptor gene rearrangements, breakpoint fusion regions of chromosome aberrations, fusion-gene transcripts, aberrant genes, or aberrantly expressed… Expand
PCR for monitoring of minimal residual disease in hematologic malignancy.
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