Detection of minimal residual disease in acute leukemia: methodologic advances and clinical significance.

@article{Campana1995DetectionOM,
  title={Detection of minimal residual disease in acute leukemia: methodologic advances and clinical significance.},
  author={Dario Campana and C. H. Pui},
  journal={Blood},
  year={1995},
  volume={85 6},
  pages={1416-34}
}
A T DIAGNOSIS, PATIENTS WITH acute leukemia may have a total of approximately 10l2 malignant cells.',2 The disease is considered to be in complete remission when fewer than 5% of the cells in bone marrow (BM) samples are morphologically identifiable blasts. However, these patients may still have as many as IO'" neoplastic cells. From that point until overt clinical relapse, the level of leukemic cells in the body is largely unknown, resulting in clinical management strategies that do not… CONTINUE READING
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