Detection of microsatellite instability in colorectal cancer using an alternative multiplex assay of quasi-monomorphic mononucleotide markers.

@article{Deschoolmeester2008DetectionOM,
  title={Detection of microsatellite instability in colorectal cancer using an alternative multiplex assay of quasi-monomorphic mononucleotide markers.},
  author={Vanessa Deschoolmeester and Marc F. D. Baay and Wim Wuyts and Eric van Marck and Nancy van Damme and Peter Vermeulen and Krzysztof Lukaszuk and Filip Lardon and Jan Baptist Vermorken},
  journal={The Journal of molecular diagnostics : JMD},
  year={2008},
  volume={10 2},
  pages={154-9}
}
Colorectal malignancies demonstrating microsatellite instability (MSI) have a very heterogeneous histological appearance, better prognosis, and altered response to therapy. Consequently, identification of the MSI phenotype is both relevant and interesting as a screening and prognostic tool and as a potential predictive factor of chemotherapeutic response. Several groups have argued for the exclusive use of mononucleotide markers for MSI analysis. In this study, an alternative MSI typing… CONTINUE READING
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