Detection of micrometastases in sentinel lymph nodes from melanoma patients: direct comparison of multimarker molecular and immunopathological methods.

@article{Rimoldi2003DetectionOM,
  title={Detection of micrometastases in sentinel lymph nodes from melanoma patients: direct comparison of multimarker molecular and immunopathological methods.},
  author={Donata Rimoldi and Robert Lemoine and A Kurt and Suzanne Salvi and Magali Berset and Maurice Matter and Bruno Roche and Jean-Philippe Cerottini and David Guggisberg and Joachim Krischer and Ralph Braun and Jean-Pierre Willi and Christian Antonescu and Daniel Slosman and Ferdy J. Lejeune and Danielle Li{\'e}nard},
  journal={Melanoma research},
  year={2003},
  volume={13 5},
  pages={511-20}
}
The technique of sentinel lymph node (SLN) dissection is a reliable predictor of metastatic disease in the lymphatic basin draining the primary melanoma. Reverse transcription-polymerase chain reaction (RT-PCR) is emerging as a highly sensitive technique to detect micrometastases in SLNs, but its specificity has been questioned. A prospective SLN study in melanoma patients was undertaken to compare in detail immunopathological versus molecular detection methods. Sentinel lymphadenectomy was… CONTINUE READING

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