Detection of methylthioadenosine phosphorylase (MTAP) and p16 gene deletion in T cell acute lymphoblastic leukemia by real-time quantitative PCR assay

@article{Msoka2000DetectionOM,
  title={Detection of methylthioadenosine phosphorylase (MTAP) and p16 gene deletion in T cell acute lymphoblastic leukemia by real-time quantitative PCR assay},
  author={T M'soka and Junji Nishioka and Atsushi Taga and Koji Kato and Hirohide Kawasaki and Yasuaki Yamada and Alexander Fangxiao Yu and Yoshihiro Komada and Tsutomu Nobori},
  journal={Leukemia},
  year={2000},
  volume={14},
  pages={935-940}
}
Methylthioadenosine phosphorylase (MTAP) deficiency in tumors can be therapeutically exploited for selective therapy. Many tumors lacking MTAP have been found to homozygously delete the chromosome 9p region containing the p16 tumor suppressor gene. Several methods have been used to detect chromosome 9p deletions in primary tumors. However, the accurate diagnosis of chromosome 9p deletions has been hampered by the presence of contaminating normal cells. In search of an accurate and sensitive… CONTINUE READING

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