Detection of methylphenidate in the hair of children treated with Ritalin.

@article{Sticht2007DetectionOM,
  title={Detection of methylphenidate in the hair of children treated with Ritalin.},
  author={Guido Sticht and Katrin Sevecke and Herbert K{\"a}ferstein and Manfred D{\"o}pfner and Markus Alexander Rothschild},
  journal={Journal of analytical toxicology},
  year={2007},
  volume={31 9},
  pages={
          588-91
        }
}
Hair samples were collected from 17 children (7-16 years of age) who had received methylphenidate therapy on a long-term basis. The dose was 10-60 mg per day. To 20 mg of pulverized hair, phosphate buffer and internal standard (norpethidine) were added. Extraction was performed by ultrasonic treatment, followed by isolation by alkaline extraction with isohexane. Derivatization with N-Methyl-bisheptafluorobutyric amide enabled gas chromatography-mass spectrometry analysis of the perfluorobutyryl… Expand
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