Detection of methylphenidate in the hair of children treated with Ritalin.

  title={Detection of methylphenidate in the hair of children treated with Ritalin.},
  author={Guido Sticht and Katrin Sevecke and Herbert K{\"a}ferstein and Manfred D{\"o}pfner and Markus Alexander Rothschild},
  journal={Journal of analytical toxicology},
  volume={31 9},
Hair samples were collected from 17 children (7-16 years of age) who had received methylphenidate therapy on a long-term basis. The dose was 10-60 mg per day. To 20 mg of pulverized hair, phosphate buffer and internal standard (norpethidine) were added. Extraction was performed by ultrasonic treatment, followed by isolation by alkaline extraction with isohexane. Derivatization with N-Methyl-bisheptafluorobutyric amide enabled gas chromatography-mass spectrometry analysis of the perfluorobutyryl… Expand
Simultaneous determination of methylphenidate and ritalinic acid in hair using LC-MS/MS.
Hair analysis and background findings revealed that most subjects have abused illicit substances (methamphetamine, Δ9-tetrahydrocannabinol, zolpidem etc.) other than MPH and the low picogram range of LODs for MPH and RA in hair was achieved with the present method. Expand
Violence under the influence of methylphenidate as determined by hair analysis
A 26-year-old woman under the influence of alcohol assaulted another person at a party in late November 2008. Afterward, she claimed that her drink was spiked with Ritalin, which would account forExpand
Assault under the influence of methylphenidate documented by hair analysis
Hair sampling is a useful complement to blood and urine analyses to increase the window of detection and to permit differentiation of a single exposure from chronic use of a drug by segmentation. Expand
Concentrations of Antidepressants, Antipsychotics, and Benzodiazepines in Hair Samples from Postmortem Cases
The comprehensive data on postmortem hair concentrations for antidepressants, antipsychotics, and benzodiazepines may help other investigators in their casework and should be interpreted carefully and preferably include segmental analysis and metabolite/parent drug ratios to exclude possible contamination. Expand
HPLC determination of methylphenidate and its metabolite, ritalinic acid, by high-performance liquid chromatography with peroxyoxalate chemiluminescence detection
An HPLC–peroxyoxalate chemiluminescence (PO-CL) method for simultaneous determination of methylphenidate (MPH) and ritalinic acid (RA) and was successfully used to monitor these substances after MPH administration. Expand
Hair analysis of antidepressants and antipsychotics - overview of quantitative data.
Although hair analysis research focused mainly on drugs abuse, contribution of more data on antidepressants and antipsychotics would help to gain better knowledge and assistance for other forensic investigators. Expand
Particle-size distribution (PSD) of pulverized hair: A quantitative approach of milling efficiency and its correlation with drug extraction efficiency.
A good correlation was obtained between PSD results and ketamine concentration in a hair sample analyzed by LC-MS/MS, and PSD is a key feature on analysis of pulverized hair as it can affect the method recovery and reproducibility. Expand
Metilfenidato en el tratamiento del trastorno de déficit de atención con hiperactividad en pediatría: monitorización en matrices biológicas
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Interindividual dose/concentration relationship for methadone in hair.
No interindividual correlation between prescribed dose and concentration of methadone in hair was observed and the dose/concentration relationship for methad one was investigated. Expand
Qualitative screening for drugs of abuse in hair using GC-MS.
A previously described method for the analysis of hair has been modified to include analysis for amphetamines, benzodiazepines, cocaine and its metabolites, methadone and its metabolite, andExpand
Pharmacokinetics of methylphenidate in hyperkinetic children.
The brief half life ofethylphenidate which parallels the short duration of action of methylphenidate in behaviorally disordered children may be explained in part by its low protein binding which results in high percentage of free drug being made available for metabolism to pharmacologically inactive metabolites. Expand
Detection of ritalinic acid in urine by thin-layer chromatography and gas chromatography.
A new method for the analysis of ritalinic acid, the major metabolite of methylphenidate in urine, is described, which gives essentially quantitative recovery of ritalsinic acid from 10 mL urine and is linear in the range of 0 to 10 micrograms/mL. Expand
A reproducible gas chromatographic mass spectrometric assay for low levels of methylphenidate and ritalinic acid in blood and urine.
A rapid, sensitive method of analysis for methylphenidate and ritalinic acid in blood and urine has been developed using gas chromatography mass spectrometry and selected ion monitoring forExpand
The scientific foundation for understanding attention-deficit/hyperactivity disorder as a valid psychiatric disorder
  • S. Faraone
  • Psychology, Medicine
  • European child & adolescent psychiatry
  • 2005
Evidence is presented to show that ADHD meets the criteria for a valid psychiatric diagnosis and has a biological basis and a characteristic response to treatment, which support the idea that ADHD is a valid diagnostic category. Expand
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
This material was developed by Duke University, funded by the Department of Health and Human Services, Office of the National Coordinator for Health Information Technology under Award NumberExpand