Detection of melanocortin-1 receptor antigenicity on human skin cells in culture and in situ.

@article{Bhm1999DetectionOM,
  title={Detection of melanocortin-1 receptor antigenicity on human skin cells in culture and in situ.},
  author={Markus B{\"o}hm and Dieter Metze and U. Schulte and Eva Becher and Thomas Anton Luger and Thomas Brzoska},
  journal={Experimental dermatology},
  year={1999},
  volume={8 6},
  pages={453-61}
}
The proopiomelanocortin (POMC) products alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropin (ACTH) bind to specific receptors known as the melanocortin (MC) receptors. There is increasing evidence that the MC receptor subtype 1 (MC-1R) is expressed in vitro by several other cutaneous cell types besides melanocytes and keratinocytes. Our knowledge on the MC-1R expression in skin, however, remains fragmentary. In order to examine the expression of MC-1R in human skin cells in… CONTINUE READING