Detection of malondialdehyde in vivo using microdialysis sampling with CE-fluorescence.

  title={Detection of malondialdehyde in vivo using microdialysis sampling with CE-fluorescence.},
  author={Justin Carl Cooley and Craig Edward Lunte},
  volume={32 21},
Oxidative damage is a naturally occurring process where reactive oxygen species (ROS) attack and disrupt normal cellular function; however, these effects become elevated during a stress event, such as ischemia/reperfusion or seizure. One result of oxidative stress is lipid peroxidation, where ROS attack free unsaturated fatty acids forming lipid hydorperoxides, which then break down to form secondary products acrolein, 4-hydroxynonenal, and malondialdehyde (MDA) resulting in irreversible… CONTINUE READING
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