Detection of major histocompatibility complex/human cartilage gp-39 complexes in rheumatoid arthritis synovitis as a specific and independent histologic marker.

@article{Baeten2004DetectionOM,
  title={Detection of major histocompatibility complex/human cartilage gp-39 complexes in rheumatoid arthritis synovitis as a specific and independent histologic marker.},
  author={D. Baeten and Peter G. A. Steenbakkers and Antonius W. M. Rijnders and Annemieke M. H. Boots and Eric Maximilien Veys and Filip de Keyser},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 2},
  pages={
          444-51
        }
}
OBJECTIVE Peptide 263-275 is the immunodominant epitope of human cartilage (HC) gp-39, a candidate autoantigen in rheumatoid arthritis (RA). We recently generated and characterized a monoclonal antibody (mAb) called 12A, which is directed against HLA-DR4/HC gp-39(263-275) complexes and inhibits specific T cell responses in vitro. The aim of the present study was to analyze whether presentation of the immunodominant epitope of HC gp-39 by shared epitope-positive synovial dendritic cells is a… CONTINUE READING
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