Detection of major gene for Gilles de la Tourette syndrome.

  title={Detection of major gene for Gilles de la Tourette syndrome.},
  author={David E. Comings and B G Comings and Eric J. Devor and C. Robert Cloninger},
  journal={American journal of human genetics},
  volume={36 3},
The families of 250 consecutive, unselected patients with Tourette syndrome (TS) were analyzed. If the parents had either motor or vocal tics, but not both, there was an increased risk of both TS and tics in the offspring. The mode of inheritance of the combined tic-Tourette trait was evaluated in both nuclear families and extended pedigrees. Complex segregation analysis was carried out allowing for possible contributions from both a major autosomal locus and multifactorial inheritance of… CONTINUE READING


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