Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes.

@article{Hukkanen1997DetectionOM,
  title={Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes.},
  author={Janne Hukkanen and Jukka Hakkola and Sisko Anttila and Ritva Piipari and Antti Karjalainen and Olavi Pelkonen and Hannu Raunio},
  journal={Molecular carcinogenesis},
  year={1997},
  volume={20 2},
  pages={224-30}
}
Human pulmonary tissue are known to contain enzymes mediating procarcinogen activation. Peripheral blood lymphocytes and bronchoalveolar macrophages (BAMs) have been used as surrogates for the lung in studies involving cytochrome P450 (CYP) parameters, including CYP1A1 inducibility in relation to susceptibility to lung cancer. In this study, a comprehensive view of the expression patterns of xenobiotic-metabolizing CYP forms in human BAMs and peripheral blood lymphocytes was obtained by using… CONTINUE READING