Detection of low-level K65R variants in nucleoside reverse transcriptase inhibitor-naive chronic and acute HIV-1 subtype C infections.

@article{Li2011DetectionOL,
  title={Detection of low-level K65R variants in nucleoside reverse transcriptase inhibitor-naive chronic and acute HIV-1 subtype C infections.},
  author={Jin-fen Li and Jonathan T Lipscomb and Xierong Wei and Neil Alexander Martinson and Lynn Morris and Walid Heneine and Jeffrey A. Johnson},
  journal={The Journal of infectious diseases},
  year={2011},
  volume={203 6},
  pages={798-802}
}
To substantiate reports of greater emergence of the K65R nucleoside reverse transcriptase inhibitor (NRTI) mutation in human immunodeficiency virus type 1 (HIV-1) subtype C, we examined natural low-level K65R expression in subtype C relative to subtypes B and AE. We used allele-specific polymerase chain reaction to screen HIV-1 amplified by reverse-transcription high-fidelity polymerase chain reaction from subtype C-infected South African women and infants and CRF01(subtype AE) from Thailand… CONTINUE READING