Detection of likely transmembrane beta strand regions in sequences of mitochondrial pore proteins using the Gibbs sampler.

@article{Mannella1996DetectionOL,
  title={Detection of likely transmembrane beta strand regions in sequences of mitochondrial pore proteins using the Gibbs sampler.},
  author={Carmen A. Mannella and Andrew F. Neuwald and Charles E Lawrence},
  journal={Journal of bioenergetics and biomembranes},
  year={1996},
  volume={28 2},
  pages={163-9}
}
The mitochondrial channel VDAC is presumed to fold as a beta-barrel although the number and identity of transmembrane beta-strands in the protein are controversial. Previously, a novel multiple alignment algorithm called the Gibbs sampler was used to detect a residue-frequency motif in sequences of bacterial outer-membrane proteins that corresponds to transmembrane beta-strands in bacterial porins of known structure (Neuwald et al., 1995, Protein Science, 4, 1618. In the present study, this… CONTINUE READING

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