Detection of latent varicella zoster virus DNA and human gene sequences in human trigeminal ganglia by in situ amplification combined with in situ hybridization

@article{Dueland1995DetectionOL,
  title={Detection of latent varicella zoster virus DNA and human gene sequences in human trigeminal ganglia by in situ amplification combined with in situ hybridization},
  author={A. N. Dueland and Toril Ranneberg-Nilsen and Miklos Degr{\'e}},
  journal={Archives of Virology},
  year={1995},
  volume={140},
  pages={2055-2066}
}
Varicella zoster virus (VZV) establishes latency in sensory ganglia following primary infection (chickenpox) and may reactivate decades later to produce zoster (shingles). The presence of VZV DNA in latently infected ganglia has been demonstrated by Southern blot hybridization as well as by polymerase chain reaction of DNA extracted from latently infected ganglia. Conflicting results have been obtained by in situ hybridization studies to determine the cell type in the ganglia harboring the… CONTINUE READING
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