Detection of known and novel ALK fusion transcripts in lung cancer patients using next-generation sequencing approaches

@inproceedings{Vendrell2017DetectionOK,
  title={Detection of known and novel ALK fusion transcripts in lung cancer patients using next-generation sequencing approaches},
  author={Julie A. Vendrell and Sylvie Taviaux and Beno{\^i}t B{\'e}ganton and Sylvain Godreuil and Patricia Audran and David Grand and Estelle Clermont and Isabelle Serre and Vanessa Szablewski and Peter J. Coopman and Julien Mazi{\`e}res and Val{\'e}rie Costes and Jean-Louis Pujol and P. Brousset and Isabelle Rouquette and J{\'e}r{\^o}me Solassol},
  booktitle={Scientific Reports},
  year={2017}
}
Rearrangements of the anaplastic lymphoma kinase (ALK) gene in non-small cell lung cancer (NSCLC) represent a novel molecular target in a small subset of tumors. Although ALK rearrangements are usually assessed by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), molecular approaches have recently emerged as relevant alternatives in routine laboratories. Here, we evaluated the use of two different amplicon-based next-generation sequencing (NGS) methods (AmpliSeq and… CONTINUE READING