Detection of katG Ser315Thr substitution in respiratory specimens from patients with isoniazid-resistant Mycobacterium tuberculosis using PCR-RFLP.

@article{Leung2003DetectionOK,
  title={Detection of katG Ser315Thr substitution in respiratory specimens from patients with isoniazid-resistant Mycobacterium tuberculosis using PCR-RFLP.},
  author={Eric Tung-Yiu Leung and Kai-Man Kam and Agatha Wai Huen Chiu and Pak-leung Ho and Wing-hong Seto and Kwok-yung Yuen and W M Yam},
  journal={Journal of medical microbiology},
  year={2003},
  volume={52 Pt 11},
  pages={999-1003}
}
Mutations in the katG locus of catalase peroxidase in Mycobacterium tuberculosis (MTB) account for major isoniazid (INH) resistance. In the South China region, a collection of 906 respiratory specimens and 142 MTB isolates was used to evaluate the sensitivity and specificity of a PCR-RFLP method for the detection of INH resistance-associated mutations… CONTINUE READING