Detection of internal cavities in globular proteins.

  title={Detection of internal cavities in globular proteins.},
  author={Simon J. Hubbard and Patrick Argos},
  journal={Protein engineering},
  volume={8 10},
We have undertaken a study of internal cavities in five protein structure groups, each containing different crystallographic structure determinations of the same protein, to understand better the nature of packing defects in protein tertiary architectures. Our results show that cavity detection and consistency of detection are highly dependent on probe and cavity size, cavity position within the globular protein and the local "quality' (r.m.s. deviation) of structural consistency within the… CONTINUE READING

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