Detection of individual human neutrophil alpha-defensins (human neutrophil peptides 1, 2 and 3) in unfractionated gingival crevicular fluid--a MALDI-MS approach.

@article{Lundy2005DetectionOI,
  title={Detection of individual human neutrophil alpha-defensins (human neutrophil peptides 1, 2 and 3) in unfractionated gingival crevicular fluid--a MALDI-MS approach.},
  author={Fionnuala T. Lundy and David Francis Orr and Christopher T. Shaw and P J Lamey and Gerard James Linden},
  journal={Molecular immunology},
  year={2005},
  volume={42 5},
  pages={575-9}
}
The role of antimicrobial peptides is particularly important in the oral cavity where there is constant challenge by microorganisms. The alpha-defensins are a group of cationic peptides that comprise 30-50% of the total protein in azurophilic granules of human neutrophils. They include the human neutrophil peptides (HNP) 1, 2 and 3 which have almost identical amino acid sequences but differ in their biological activities. The amino acid sequence similarities of the defensins have made it… CONTINUE READING
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