Detection of increased local excitatory circuits in the hippocampus during epileptogenesis using focal flash photolysis of caged glutamate.

@article{Shao2005DetectionOI,
  title={Detection of increased local excitatory circuits in the hippocampus during epileptogenesis using focal flash photolysis of caged glutamate.},
  author={Li-Rong Shao and F. Edward Dudek},
  journal={Epilepsia},
  year={2005},
  volume={46 Suppl 5},
  pages={100-6}
}
PURPOSE Local synaptic circuits, particularly recurrent excitation, are hypothesized to contribute to the generation and synchronization of epileptiform activity. The present study tested whether local excitatory circuits in the hippocampus are increased in an animal model of temporal lobe epilepsy, and thus may contribute to epileptic seizures. METHODS Rats were given hourly injections of kainic acid to induce status epilepticus, which led to chronic epilepsy with spontaneous recurrent… CONTINUE READING