Detection of human soluble Thy-1 in serum by ELISA

  title={Detection of human soluble Thy-1 in serum by ELISA},
  author={Anja Saalbach and Tino Wetzig and U. F. Haustein and Ulf Anderegg},
  journal={Cell and Tissue Research},
The functions of Thy-1, a 35-kDa cell-surface glycoprotein, and its natural ligand are still unknown. Anchoring to the membrane via linkage to phosphatidylinositol (PI) raises the possibility of cleavage off the membrane by PI-specific phospholipases. Soluble Thy-1 (sThy-1) could interfere with the binding of the unknown natural ligand followed by regulation of different cell functions. In this study we established an enzyme-linked immunosorbent assay (ELISA) to measure and quantify sThy-1 in… CONTINUE READING