Detection of human papillomavirus DNA in cytologically normal women and subsequent cervical squamous intraepithelial lesions.

@article{Liaw1999DetectionOH,
  title={Detection of human papillomavirus DNA in cytologically normal women and subsequent cervical squamous intraepithelial lesions.},
  author={K L Liaw and Andrew Glass and M. Michele Manos and Catherine E. Greer and David R Scott and Mark E. Sherman and Robert D Burk and Robert J. Kurman and Sholom Wacholder and Brenda B. Rush and D M Cadell and P J Lawler and Dennis G Tabor and Mark H. Schiffman},
  journal={Journal of the National Cancer Institute},
  year={1999},
  volume={91 11},
  pages={954-60}
}
BACKGROUND Human papillomavirus (HPV) infection has been strongly associated with cervical carcinoma and its cytologic precursors, squamous intraepithelial lesions (SIL). We investigated the risk of SIL prospectively following polymerase chain reaction (PCR)-based DNA testing for a wide range of genital HPV types in a cohort of initially cytologically normal women, to clarify the role of HPV in the etiology of SIL. METHODS Starting in April 1989, 17,654 women who were receiving routine… CONTINUE READING

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