Detection of human herpesvirus-8 in peripheral blood mononuclear cells from adult Japanese patients with multicentric Castleman's disease.

@article{Yamasaki2003DetectionOH,
  title={Detection of human herpesvirus-8 in peripheral blood mononuclear cells from adult Japanese patients with multicentric Castleman's disease.},
  author={Satoshi Yamasaki and Tadafumi Iino and Minoru Nakamura and Hideho Henzan and Koichi Ohshima and Masahiro Kikuchi and Teruhisa Otsuka and M. D. N. Harada},
  journal={British journal of haematology},
  year={2003},
  volume={120 3},
  pages={471-7}
}
Human herpesvirus-8 (HHV-8) encodes viral homologues of cellular genes, including viral interleukin 6 (vIL-6), which induces endogenous human IL-6 (hIL-6) secretion. Unregulated overproduction of hIL-6 in lymph nodes (LN) is thought to be responsible for the systemic manifestations of multicentric Castleman's disease (MCD). In the present study, we assessed the presence of HHV-8 and HHV-8-encoded viral homologues in LN and peripheral blood mononuclear cells (PBMC) from adult Japanese patients… CONTINUE READING

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