Detection of high-risk human papillomavirus subtypes in cervical glandular neoplasia by in situ hybridization.

@article{Sheng2013DetectionOH,
  title={Detection of high-risk human papillomavirus subtypes in cervical glandular neoplasia by in situ hybridization.},
  author={Zhang Sheng and Hiroshi Minato and Toshiyuki Sasagawa and Satoko Nakada and Eriko Kinoshita and Nozomu Kurose and Takayuki Nojima and Satoru Makinoda},
  journal={International journal of clinical and experimental pathology},
  year={2013},
  volume={6 10},
  pages={2168-77}
}
In situ hybridization (ISH) was performed on paraffin-embedded tissues to detect multiple high-risk human papillomavirus (HPV) subtypes in 27 cases of cervical adenocarcinoma in situ (AIS) and adenocarcinoma (CA) specimens. These results were compared with those of HPV detection by HPV-PCR genotyping and p16 immunohistochemistry in the same specimens. Of the 27 cases, 17 (63%) showed HPV-DNA by HPV-ISH, including 3 metastatic lesions. HPV-DNA was detected in 18 cases (67%) by PCR. The… CONTINUE READING

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