Detection of high-risk HPV in head and neck squamous cell carcinomas: comparison of chromogenic in situ hybridization and a reverse line blot method.

@article{Stevens2011DetectionOH,
  title={Detection of high-risk HPV in head and neck squamous cell carcinomas: comparison of chromogenic in situ hybridization and a reverse line blot method.},
  author={Todd M Stevens and Samuel K Caughron and S. Terence Dunn and Joseph A Knezetic and Zoran Gatalica},
  journal={Applied immunohistochemistry & molecular morphology : AIMM},
  year={2011},
  volume={19 6},
  pages={574-8}
}
Human papillomaviruses (HPVs) have been etiologically linked to a subset of head and neck squamous cell carcinomas (HNSCCs), generally arising in young patients without a history of tobacco smoking or alcohol use. These tumors typically lack mutations in TP53 and may show enhanced sensitivity to chemoradiation therapy with a correspondingly better overall prognosis. The determination of the HPV status in HNSCC therefore has therapeutic implications. We compared the Ventana ISH iView Blue Plus… CONTINUE READING