Detection of herpes-simplex viral genome in brain tissue.


Herpes-simplex virus type (HSV-1) nucleic-acid sequences were detected by in-situ hybridisation in thin sections of brains from mice which had been inoculated 24 weeks previously with HSV-1. These mice were not ill, and infectious virus could not be recovered from them. HSV-1 sequences were also present in brain smears from 3 of 4 elderly patients who had… (More)


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