Detection of hepatocellular carcinoma-specific alpha-fetoprotein by isoelectric focusing.

BACKGROUND Serum alpha-fetoprotein (AFP) is elevated in up to 80% of patients with hepatocellular carcinoma (HCC). Modestly raised AFP levels (10-400 ng/ml) are also found in patients with nonmalignant liver diseases. In the present study, isoelectric focusing of AFP was used to differentiate the AFP found in patients with HCC. METHODS To establish the… CONTINUE READING