Detection of hepatitis C virus RNA in hepatocellular carcinoma by in situ hybridization.

@article{Tang1995DetectionOH,
  title={Detection of hepatitis C virus RNA in hepatocellular carcinoma by in situ hybridization.},
  author={Liang Tang and Yuka Tanaka and Nobuyuki Enomoto and Fumiaki Marumo and Chifumi Sato},
  journal={Cancer},
  year={1995},
  volume={76 11},
  pages={
          2211-6
        }
}
BACKGROUND Hepatocellular carcinoma frequently is associated with chronic hepatitis C virus (HCV) infection. The presence of HCV in hepatocellular carcinoma has been detected by reverse-transcription polymerase chain reaction of antigenomic HCV RNA, a tissue-specific replicative form of the virus. Now, however, this method of detecting the presence of HCV has been invalidated by reports of antigenomic RNA in the blood or in peripheral blood mononuclear cells. METHODS In situ hybridization of… CONTINUE READING

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