Detection of hepatitis B virus antigens in liver tissue. A relation to viral replication and histology in chronic hepatitis B infection.

@article{Naoumov1990DetectionOH,
  title={Detection of hepatitis B virus antigens in liver tissue. A relation to viral replication and histology in chronic hepatitis B infection.},
  author={Nikolai V. Naoumov and Bernard C. Portmann and Richard S. Tedder and B Ferns and Adrian L. W. F. Eddleston and Graeme J. M. Alexander and Roger Williams},
  journal={Gastroenterology},
  year={1990},
  volume={99 4},
  pages={1248-53}
}
The expression of hepatitis B virus antigens was studied by double staining liver tissue with appropriate antisera and correlated with serum hepatitis B viral DNA and histology in 28 patients with disease related to chronic hepatitis B virus infection. The cellular localization of hepatitis B core and hepatitis B e antigens generally coincided, but there were important differences at a subcellular level. Thus, hepatitis B e antigen was detected in nuclei and/or cytoplasm but strong cytoplasmic… CONTINUE READING
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