Detection of gymnodimine-A and 13-desmethyl C spirolide phycotoxins by fluorescence polarization.

@article{Vilario2009DetectionOG,
  title={Detection of gymnodimine-A and 13-desmethyl C spirolide phycotoxins by fluorescence polarization.},
  author={Natalia Vilari{\~n}o and Eva S. Fonfr{\'i}a and Jordi Molg{\'o} and R{\'o}mulo Ar{\'a}oz and Luis M. Botana},
  journal={Analytical chemistry},
  year={2009},
  volume={81 7},
  pages={2708-14}
}
The gymnodimines and spirolides are phycotoxins classified into a heterogeneous group of marine biocompounds called cyclic imines. Although there is no clear evidence of their toxicity to humans, gymnodimines and spirolides are highly toxic to rodents and constitute a source of false positives in lipophilic toxin detection by the mouse bioassay. Using nicotinic acetylcholine receptor-enriched membranes of Torpedo, and fluorescent alpha-bungarotoxin, we developed a fluorescence polarization… CONTINUE READING
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