Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis.

@article{Tamura1991DetectionOF,
  title={Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis.},
  author={Goshu Tamura and Toshimasa Kihana and Kazuhiro Nomura and Masaaki Terada and Takashi Sugimura and Setsuo Hirohashi},
  journal={Cancer research},
  year={1991},
  volume={51 11},
  pages={3056-8}
}
Mutations of the p53 gene were investigated after tumor cell enrichment by cell sorting based on differences in DNA content and polymerase chain reaction single-strand conformation polymorphism analysis in 24 surgical specimens of primary gastric cancer. p53 mutations were detected in exons 4-8 in 64% (9 of 14) of aneuploid tumors but in none of 10 diploid tumors examined. Four of five tumors containing two or three aneuploid subpopulations showed the presence of p53 gene mutations. No… CONTINUE READING

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