Detection of fragmented genomic DNA by PCR-free piezoelectric sensing using a denaturation approach.

@article{Minunni2005DetectionOF,
  title={Detection of fragmented genomic DNA by PCR-free piezoelectric sensing using a denaturation approach.},
  author={Maria Minunni and Sara Tombelli and Jessica Fonti and Maria Michela Spiriti and Marco Mascini and Patrizia Bogani and Marcello Buiatti},
  journal={Journal of the American Chemical Society},
  year={2005},
  volume={127 22},
  pages={7966-7}
}
Label-free and real-time DNA sequence detection in PCR-amplified DNA samples can now be achieved by different approaches. On the contrary, only few works have been reported dealing with direct sequence detection in nonamplified genomic DNA. Here, a piezoelectric biosensor for direct detection of sequences in nonamplified genomic DNA is described. The system relies on real-time and label-free detection of the hybridization reaction between an immobilized probe and the complementary sequence in… CONTINUE READING

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