Detection of five new hydroxyl analogues of azaspiracids in shellfish using multiple tandem mass spectrometry.

@article{James2003DetectionOF,
  title={Detection of five new hydroxyl analogues of azaspiracids in shellfish using multiple tandem mass spectrometry.},
  author={Kevin J James and Monica Diaz Sierra and Mary Lehane and Ana Bra{\~n}a Magdalena and Ambrose Furey},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2003},
  volume={41 3},
  pages={277-83}
}
The polyether dinoflagellate toxins, azaspiracids, are responsible for azaspiracid poisoning (AZP), a new human toxic syndrome arising from the consumption of shellfish. To date, five azaspiracids have been isolated and fully structurally elucidated, including, AZA1, its 8-methyl and 22-demethyl analogues, AZA2 and AZA3, respectively, and two hydroxyl derivatives of AZA3, named AZA4 and AZA5. Using a recently developed method involving liquid chromatography with multiple tandem mass… CONTINUE READING