Detection of fetal cells in transcervical samples and prenatal diagnosis of chromosomal abnormalities.

@article{Adinolfi1995DetectionOF,
  title={Detection of fetal cells in transcervical samples and prenatal diagnosis of chromosomal abnormalities.},
  author={Matteo Adinolfi and Jon K. Sherlock and Boris Tutschek and Amiya Halder and Joy D. A. Delhanty and Charles Rodeck},
  journal={Prenatal diagnosis},
  year={1995},
  volume={15 10},
  pages={
          943-9
        }
}
Transcervical samples collected by lavage, aspiration, and cytobrush from women between 6 and 13 weeks of gestation were tested for the presence of fetal cells using fluorescence in situ hybridization (FISH) with probes for chromosomes X, Y, 1, and 21, and by polymerase chain reaction (PCR) amplification of DNA sequences derived from chromosomes X, Y, and 21. With a few exceptions, a good correlation was observed between the results of sexing the fetuses using FISH or PCR on transcervical cell… CONTINUE READING
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