Detection of femtomolar proteins by nonfluorescent ZnS nanocrystal clusters.

  title={Detection of femtomolar proteins by nonfluorescent ZnS nanocrystal clusters.},
  author={Jingjing Yao and X. Han and S. Zeng and W. Zhong},
  journal={Analytical chemistry},
  volume={84 3},
  • Jingjing Yao, X. Han, +1 author W. Zhong
  • Published 2012
  • Chemistry, Medicine
  • Analytical chemistry
  • Cation exchange (CX) in the nonfluorescent ZnS nanocrystal clusters (NCCs) was employed to detect trace biomolecules with immunoassays. The NCCs were porous and allowed fast cation exchange reaction to release an ultralarge number of Zn(2+) from each cluster that turned on the Zn-responsive dyes for fluorescence detection. The ZnS NCCs were highly stable in biological buffers and more biocompatible than quantum dots. Zn(2+) release efficiency and target binding by NCCs with average diameters of… CONTINUE READING
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