Detection of exosomal prions in blood by immunochemistry techniques.

  title={Detection of exosomal prions in blood by immunochemistry techniques.},
  author={Francesca Properzi and Mariantonia Logozzi and Hanin Abdel-Haq and Cristina Federici and Luana Lugini and Tommaso Azzarito and Ilaria Cristofaro and Daniela di Sevo and Elena Ferroni and Franco Cardone and Massimo Venditti and Marisa Colone and Emmanuel E. Comoy and Val{\'e}rie Durand and Stefano Fais and Maurizio Pocchiari},
  journal={The Journal of general virology},
  volume={96 Pt 7},
In most forms of prion diseases, blood is infectious, but detection by immunochemistry techniques of the only available marker of infection (the misfolded prion protein, PrPTSE) in blood remains elusive. We developed a novel method for the detection of PrPTSE in blood of prion-infected rodents based on the finding that PrPTSE is associated with plasma exosomes. However, further purification of the exosomes on a sucrose gradient was necessary to remove plasma immunoglobulins, which interfere… CONTINUE READING
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