Detection of erbB-2 amplifications in tumors and sera from esophageal carcinoma patients.

@article{Chiang1999DetectionOE,
  title={Detection of erbB-2 amplifications in tumors and sera from esophageal carcinoma patients.},
  author={Pei Wen Chiang and David G Beer and Wen-Qiang Wei and Mark B. Orringer and David M. Kurnit},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1999},
  volume={5 6},
  pages={1381-6}
}
We used TaqMan PCR to detect quantitative anomalies of tumor markers in both tumor and serum DNA from esophageal cancer patients. We demonstrated the potential of this methodology by detecting erbB-2 amplifications in a plurality of esophageal tumor samples. These amplifications were corroborated by Southern blots. We then showed the potential of this methodology to detect quantitative anomalies of erbB-2 in serum DNA from individuals with a corresponding amplification in the tumor. The… CONTINUE READING

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