Detection of epithelial cancer cells in peripheral blood by reverse transcriptase-polymerase chain reaction.

@article{Burchill1995DetectionOE,
  title={Detection of epithelial cancer cells in peripheral blood by reverse transcriptase-polymerase chain reaction.},
  author={Susan Ann Burchill and Malcolm Bradbury and Ka Pittman and Jennifer Southgate and Brian Smith and Prideaux John Selby},
  journal={British Journal of Cancer},
  year={1995},
  volume={71},
  pages={278 - 281}
}
Circulating cancer cells in the blood play a central role in the metastatic process. Their number can be very small and techniques for their detection need to be both sensitive and specific. Polymerase chain reaction (PCR) has been successfully used to detect small numbers of tumour cells in haematological cancer in which abnormalities in DNA are sufficiently consistent to make this possible. For most solid tumours this not yet feasible. However, we have found that reverse transcriptase (RT… CONTINUE READING
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