Detection of endogenous human cytomegalovirus in CD34+ bone marrow progenitors.

  title={Detection of endogenous human cytomegalovirus in CD34+ bone marrow progenitors.},
  author={Marc Mendelson and Simon Monard and Patrick J G Sissons and John Sinclair},
  journal={The Journal of general virology},
  volume={77 ( Pt 12)},
The cellular sites and mechanisms of human cytomegalovirus (HCMV) latency are still poorly defined. Although evidence suggests that peripheral blood monocytes are one site of latency in the healthy carrier, it is unlikely that monocytes represent a site of primary HCMV infection. Consequently, we have analysed CD34+ bone marrow progenitors, precursors of monocytes, to determine whether they are a site of HCMV carriage in normal virus carriers. For the first time, we demonstrate the presence of… CONTINUE READING

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Human cytomegalovirus: pathogenesis and models of latency

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