Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver.

  title={Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver.},
  author={Amarendra Kumar Chaudhary and Munetaka Nokubo and G. Ramachandra Reddy and S. N. D. C. O. E. R. C. Yeola and Jason D. Morrow and Ian A Blair and Lawrence J Marnett},
  volume={265 5178},
Endogenous DNA adducts may contribute to the etiology of human genetic disease and cancer. One potential source of endogenous DNA adducts is lipid peroxidation, which generates mutagenic carbonyl compounds such as malondialdehyde. A sensitive mass spectrometric method permitted detection and quantitation of the major malondialdehyde-DNA adduct, a pyrimidopurinone derived from deoxyguanosine. DNA from disease-free human liver was found to contain 5400 adducts per cell, a frequency comparable to… CONTINUE READING

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