Detection of early stage atherosclerotic plaques using PET and CT fusion imaging targeting P-selectin in low density lipoprotein receptor-deficient mice.

@article{Nakamura2013DetectionOE,
  title={Detection of early stage atherosclerotic plaques using PET and CT fusion imaging targeting P-selectin in low density lipoprotein receptor-deficient mice.},
  author={Ikuko Nakamura and Koki Hasegawa and Yasuhiro Wada and Tetsuaki Hirase and Koichi Node and Yasuyoshi Watanabe},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={433 1},
  pages={47-51}
}
BACKGROUND Sensitive detection and qualitative analysis of atherosclerotic plaques are in high demand in cardiovascular clinical settings. The leukocyte-endothelial interaction mediated by an adhesion molecule P-selectin participates in arterial wall inflammation and atherosclerosis. METHODS AND RESULTS A (64)Cu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugated anti-P-selectin monoclonal antibody ((64)Cu-DOTA-anti-P-selectin mAb) probe was prepared by conjugating an anti-P… CONTINUE READING

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