Detection of dystrophin in the postsynaptic density of rat brain and deficiency in a mouse model of Duchenne muscular dystrophy.

@article{Kim1992DetectionOD,
  title={Detection of dystrophin in the postsynaptic density of rat brain and deficiency in a mouse model of Duchenne muscular dystrophy.},
  author={Tae Won Kim and Kuo Wu and Jian Long Xu and Ira B. Black},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 23},
  pages={11642-4}
}
Duchenne muscular dystrophy (DMD) is a common, lethal, chromosome X-linked inherited disease. Moderate cognitive impairment is a feature of DMD, but the underlying mechanisms are unknown. DMD is characterized by a defect in a protein, dystrophin, that is located predominantly in muscle but has been detected in brain. We sought to directly localize dystrophin within the complex synaptic structure of the cerebral cortex by focusing on the postsynaptic density (PSD), which appears to be central to… CONTINUE READING

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