Detection of drug bioactivation in vivo: mechanism of nevirapine-albumin conjugate formation in patients.

Abstract

The non-nucleoside reverse transcriptase inhibitor nevirapine (NVP) is widely used for the treatment of human immunodeficiency virus type 1 (HIV-1), particularly in developing countries. Despite its therapeutic benefits, NVP has been associated with skin and liver injury in exposed patients. Although the mechanism of the tissue injury is not yet clear, it… (More)
DOI: 10.1021/tx4000107

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@article{Meng2013DetectionOD, title={Detection of drug bioactivation in vivo: mechanism of nevirapine-albumin conjugate formation in patients.}, author={Xiaoli Meng and Alice Howarth and Caroline J Earnshaw and Rosalind E. Jenkins and Neil S French and David J. Back and Dean J Naisbitt and B. Kevin Park}, journal={Chemical research in toxicology}, year={2013}, volume={26 4}, pages={575-83} }